Scott Buckel, Ph.D.
Assistant Professor of Biological Sciences,
College of Science and Engineering
Contact number: 281-283-3793
Email: Buckel@UHCL.edu
Office: B3531
Biography
Dr. Buckel graduated from University of Houston-Clear Lake with a Bachelor of Science, and then attended graduate school at Purdue University. I was a post-doctoral fellow at Carnegie Mellon University. After post-doctoral studies I have worked for a number of drug companies including Pitman Moore Animal Health, Parke Davis Pharmaceutical Research, Amgen and Xencor.
Areas of Expertise
- Post-translational modifications of proteins
- Elucidation of protein degradation pathways
- Protein analytical chemistry
- Development of biotech drugs
Publications
- Seely, J. E., S.D. Buckel, P. D. Green, C. W. Richey “Purification and analysis of PEGylated protein pharmaceuticals presents many challenges”. BioPharm International Mar 1, 2005
- Stoner, M.R. N. Fisher, L. Nixon, S. Buckel, M. Benke, F. Austin, T.W. Randolph and B. Kendrick “Protein-solute interactions affect the outcome of ultrafiltration/diafiltration operations”, Journal of Pharmaceutical Sciences V 93 (9), p 2332-2342 (2004)
- C.K. Edwards, S.W. Martin, J. Seely, O. Kinstler, S. Buckel, A.M. Bendele, M. Ellen Cosenza, U. Feige and T. Kohno “Design of PEGylated soluble tumor necrosis factor receptor type I (PEG sTNF-RI) for chromic inflammatory diseases” Advance Drug Delivery Reviews V55 Issue 10 p 1315-1336 (2003)
- Buckel, S.D., Cook, R.G., Crawford, M.J., Denslow, N., Madden, B.J., Steinke, L., Fernandez, J., Neveu, J.M; ABRF-2003 ESRG: Analysis of a PVDF-Bound Known Protein With a Heterogeneous Amino-Terminus Journal of Biomolecular Techniques V14, p. 278-288 (2003).
- Buckel, S.D., Cook, R.G., Crawford, J.M., Dupont, D.R., Madden, B.J., Neveu, J.M., Steinke, L., Fernandez, J.,; ABRF-2002 ESRG, A Difficult Sequence: Analysis of a PVDF-Bound Known Protein With a Heterogeneous Amino-Terminus Journal of Biomolecular Techniques V13, p246-257 (2002).
- Hu, P., Buckel, S.D., Whitton, M. H. and Loo, J. A. “Calcium Binding Properties and Sequence of Frog (Rana tegrinka) Parvalbumin as Determined by Electrospray Ionization-Mass Spectrometry” European Journal of Mass Spectrometry V 2 p 69-76 (1996)
- Buckel, S.D., Stevenson, T. I. and Loo, J. A. “Direct Mass Spectrometric Analyses for Protein Chemistry Studies” Methods in Protein Structure Analysis Ed. M. Z. Atassi and E. Appella Plenum Press, New York (1995)
- Johnson, J.L., Wimsatt, J., Buckel, S.D., Dyer, R.D., Maddipati, K.R. “Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons.” Archives of Biochemistry and Biophysics.V 324. p 26-34. (1995)
- Leng, J., Cameron, A.J., Buckel, S., Kennelly, P.J. “Isolation and cloning of a protein-serine/threonine phosphatase from an archaeon” Journal of Bacteriology.V 177. p 6510-7. (1995)
- Buckel, S.D., Cottam, PF., Simplaceanu, V., Ho, C. “Formation of intermolecular and intramolecular hydrogen bonds in histidine-binding protein J of Salmonella typhimurium upon binding L-histidine. A proton nuclear magnetic resonance study.” Journal of Molecular Biology.V 208.p 477-89 (1989)
Courses (Current Academic Year)
- BIOL4242 Laboratory for Biochemistry
- BIOT5021 Methods of Biotechnology
Research Projects
- Post-translational modifications of proteins
- Elucidation of protein degradation pathways