Nataliya Markina

Nataliya Markina, Ph.D.

Lecturer of Chemistry,
College of Science and Engineering

Contact number: 281-283-3741
Office: STEM 2246


Dr. Nataliya Markina joined the University of Houston-Clear Lake faculty in 2019 as a visiting assistant professor of chemistry. In the fall of 2021, she became a lecturer of chemistry. She received a B.S./M.S. in Chemistry from Higher Chemical College of Russian Academy of Sciences in 2008 and a Ph.D. in organic chemistry from Iowa State University in 2012. Her research is focused on developing novel synthetic methodologies for the synthesis of small heterocyclic molecules and applying the developed methods to the synthesis of combinatorial libraries. Dr. Markina is one of the co-authors of the third edition of the chemistry reference Comprehensive Organic Transformations (edited by R. C. Larock), published in 2018. 

Curriculum Vitae

Areas of Expertise

  • Organic synthesis
  • Combinatorial chemistry
  • Drug discovery


  • Markina, N. A.; Chen, Y.; Larock, R. C. “An Efficient, Microwave-assisted, One-pot Synthesis of 2,3-Disubstituted Benzofurans under Sonogashira Conditions,” Tetrahedron, 2013, 69, 2701-2713
  • Dubrovskiy, A. V.; Markina, N. A.; Larock, R. C. “Use of Benzynes in the Synthesis of Heterocycles,” Org. Biomol. Chem., 2013, 11, 191-218
  • Lu, C.; Markina, N. A.; Larock, R. C. “Synthesis of N-Acylcarbazoles through Palladium-catalyzed Aryne Annulation of ortho-Haloacetanilides,” J. Org. Chem., 2012, 77, 11153–11160
  • Rogness, D. C.; Markina, N. A.; Waldo, J. P.; Larock, R. C. “Synthesis of Pyrido[1,2-a]indole Malonates and Amines through Aryne Annulation,” J. Org. Chem., 2012, 77, 2743-2755
  • Markina, N. A.; Dubrovskiy, A. V.; Larock, R. C. “One-pot Synthesis of 1-Alkyl-1H-indazoles from 1,1-Dialkylhydrazones via Aryne Annulation,” Org. Biomol. Chem., 2012, 10, 2409-2412
  • Dubrovskiy, A. V.; Markina, N. A.; Larock, R. C. “Iodocyclization, Followed by Palladium-Catalyzed Coupling: A Versatile Strategy for Heterocyclic Library Construction: Mini-Review,” Comb. Chem. High Throughput Screen., 2012, 15, 451-472
  • Markina, N. A.; Mancuso, R.; Neuenswander, B.; Lushington, G. H.; Larock, R. C. “Solution-Phase Parallel Synthesis of a Diverse Library of 1,2-Dihydroisoquinolines,” ACS Comb. Sci. 2011, 13, 265-271
  • Chen, Y.; Markina, N. A.; Yao, T.; Larock, R. C. “Synthesis of 2,3-Disubstituted Indoles via Palladium-catalyzed Annulation of Internal Alkynes: 3-Methyl-2-(trimethylsilyl)indole,” Org. Synth. 2011, 88, 377-387
  • Chen, Y.; Markina, N. A.; Larock, R. C. “An Efficient, Microwave-assisted, One-pot Synthesis of Indoles under Sonogashira Conditions,” Tetrahedron, 2009, 65, 8908-8915

Courses (Current Academic Year)

  • Organic Chemistry I CHEM 2323 
  • Organic Chemistry II CHEM 2325
  • Organic Chemistry I Laboratory CHEM 2123 
  • Organic Chemistry II Laboratory CHEM 2125
  • Chemistry Practicum CHEM 4115